top of page

FINANCEMENT

Dr Trempe est un membre du Centre de Recherche en Biologie Structurale, un centre financé par le FRQS: 
https://www.crbsmcgill.ca/fr

INSTITUTS DE RECHERCHE EN SANTÉ DU CANADA (IRSC)

Structural and mechanistic studies of PINK1, a mitochondrial ubiquitin kinase implicated in Parkinson's disease. 

2017-2022

Principal Investigator: Jean-François Trempe

Collaborators: Gergely Lukacs, Edward Fon

Chaire de recherche du Canada en pharmacologie structurale (niveau 2)

2014-2024

CONSEIL DE RECHERCHE EN SCIENCES NATURELLES ET EN GÉNIE DU CANADA (CRSNG)

Structure-guided investigation of the mechanisms linking protein import, substrate processing, and respiration in mitochondria.

2022-2027

Principal Investigator: Jean-François Trempe

Structural and functional studies of ubiquitin kinases.

2015-2022

Principal Investigator: Jean-François Trempe

MICHAEL J FOX FOUNDATION

 

Mechanistic insights into PINK1 genetic variants

Principal Investigator: Jean-François Trempe

Structure of human PINK1-TOM complex by single-particle cryo-EM

2020-2025

Principal Investigator: Jean-François Trempe 

Co-PIs: Edward Fon, Joaquin Ortega, Mohamed Eldeeb

Characterization of new Parkin activation mutants.

2017-2020

Principal Investigator: Jean-François Trempe 

Co-PIs: Edward Fon, Thomas Durcan, Miratul Muqit, Wolfdieter Springer

Structure-based design of small-molecule activators of Parkin.

2016-2020

Principal Investigator: Jean-François Trempe

Collaborators: David Drewry, William Zuercher, Aled Edwards (SGC)

Crystal Structure of PINK1.

2016-2017

Principal Investigator: Jean-François Trempe

Collaborators: Gergely Lukacs

HEALTHY BRAIN FOR HEALTHY LIVES

Measuring protein turnover in organoid and animal models of Parkinson’s disease.

2018-2020

Principal Investigator: Jean-François Trempe

Collaborators: Thomas Durcan, Edward Fon

FONDATION CANADIENNE POUR L'INNOVATION (FCI)

Leaders Opportunity Fund (LOF) linked to Canada Research Chair. Structural Pharmacology of Parkinson's disease.

2014-2019

Principal Investigator: Jean-François Trempe

PARKINSON CANADA

Small molecule stabilizers as PINK1 agonists: a proof-of-concept study.

2017-2018

Principal Investigator: Jean-François Trempe

New Investigator Award. Crystal structure of PINK1.

2014-2016

Principal Investigator: Jean-François Trempe

©2019 par le labo du Dr Trempe. Proudly created with Wix.com

bottom of page