FINANCEMENT
Dr Trempe est un membre du Centre de Recherche en Biologie Structurale, un centre financé par le FRQS:
https://www.crbsmcgill.ca/fr
INSTITUTS DE RECHERCHE EN SANTÉ DU CANADA (IRSC)
Structural and mechanistic studies of PINK1, a mitochondrial ubiquitin kinase implicated in Parkinson's disease.
2017-2022
Principal Investigator: Jean-François Trempe
Collaborators: Gergely Lukacs, Edward Fon
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Chaire de recherche du Canada en pharmacologie structurale (niveau 2)
2014-2024
CONSEIL DE RECHERCHE EN SCIENCES NATURELLES ET EN GÉNIE DU CANADA (CRSNG)
Structural and functional studies of ubiquitin kinases.
2015-2022
Principal Investigator: Jean-François Trempe
MICHAEL J FOX FOUNDATION
Structure of human PINK1-TOM complex by single-particle cryo-EM
2020-2022
Principal Investigator: Jean-François Trempe
Co-PIs: Edward Fon, Joaquin Ortega
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Characterization of new Parkin activation mutants.
2017-2020
Principal Investigator: Jean-François Trempe
Co-PIs: Edward Fon, Thomas Durcan, Miratul Muqit, Wolfdieter Springer
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Structure-based design of small-molecule activators of Parkin.
2016-2020
Principal Investigator: Jean-François Trempe
Collaborators: David Drewry, William Zuercher, Aled Edwards (SGC)
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Crystal Structure of PINK1.
2016-2017
Principal Investigator: Jean-François Trempe
Collaborators: Gergely Lukacs
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HEALTHY BRAIN FOR HEALTHY LIVES
Measuring protein turnover in organoid and animal models of Parkinson’s disease.
2018-2020
Principal Investigator: Jean-François Trempe
Collaborators: Thomas Durcan, Edward Fon
FONDATION CANADIENNE POUR L'INNOVATION (FCI)
Leaders Opportunity Fund (LOF) linked to Canada Research Chair. Structural Pharmacology of Parkinson's disease.
2014-2019
Principal Investigator: Jean-François Trempe
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PARKINSON CANADA
Small molecule stabilizers as PINK1 agonists: a proof-of-concept study.
2017-2018
Principal Investigator: Jean-François Trempe
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New Investigator Award. Crystal structure of PINK1.
2014-2016
Principal Investigator: Jean-François Trempe